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Silibinin — the biologically most active component — can also support the synthesis of more hydrophilic and less toxic bile acid types, which may reduce the metabolic burden on hepatocytes

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors further augment immunomodulation by promoting hepatic LDL receptor recycling, thereby diminishing oxidized LDL-induced NLRP3 activation in glomerular endothelial cells (124)